Assessing a Promising Therapy for Osteoarthritis

Osteoarthritis is a common, progressive joint disease that causes pain and mobility issues for cats. Currently, no treatment exists that can safely reduce pain and stop disease progression. Researchers will study if blocking a protein called soluble epoxide hydrolase (sEH) will benefit cats suffering from osteoarthritis. Previous studies in humans have shown a possible association between sEH and the prevalence and progression of osteoarthritis. Other studies by this team in horses and mice indicate that blocking sEH can decrease joint pain and protect the joint surface from further damage. If successful, findings from this study will provide critical data on the efficacy of a novel therapy that may help improve mobility and reduce pain for thousands of cats living with osteoarthritis.